September marks the official return of must-watch television, delivering an unprecedented lineup of fresh series debuts and beloved returning favorites across Netflix, Prime Video, Hulu, and beyond. From teen drama sensations to psychological thrillers, this month’s September 2025 TV premieres promise something extraordinary for every genre enthusiast.
The Runarounds
The Runarounds debuts September 1 on Prime Video, marking the highly anticipated follow-up from Outer Banks creators Josh Pate, Jonas Pate, and Shannon Burke. This eight-episode series chronicles North Carolina teens pursuing rock stardom during their post-graduation summer, featuring actual musicians Axel Ellis, William Lipton, Jesse Golliher, and André Murillo as the fictional band members.
Executive produced by the Pate brothers alongside Shannon Burke, Scott Lambert, and Lisa Mae Brunson for Amazon MGM Studios and Skydance Television, the series required extensive musical preparation. “We wanted authenticity above all else. These aren’t actors pretending to be musicians—they’re musicians learning to act,” revealed co-creator Josh Pate during production interviews. The show’s soundtrack features original compositions, with “Funny How The Universe Works” and “Senior Year” already available for streaming ahead of the September 2025 TV premieres.
Gen V Season 2
Gen V Season 2 premieres September 17 on Prime Video, continuing The Boys universe expansion with returning stars Jaz Sinclair, Lizze Broadway, and London Thor. The eight-episode season addresses the tragic loss of Chance Perdomo, who played Andre Anderson, restructuring storylines while maintaining narrative momentum under showrunner Michele Fazekas’ direction.
Controversy emerged during production when fans criticized the decision to kill off Andre Anderson rather than recasting the role. However, executive producer Eric Kripke defended the choice, stating: “We felt honoring Chance’s memory by preserving his character’s integrity was more important than narrative convenience.” The season films at Toronto’s Cinespace Studios, with new cast additions including Hamish Linklater as the militaristic Dean Cipher.
Wednesday Season 2 Part 2
Wednesday Season 2 Part 2 arrives September 3 on Netflix, concluding Jenna Ortega’s supernatural storyline at Nevermore Academy. Directed by Tim Burton across eight episodes total, this September 2025 TV premieres highlight picks up with Wednesday recovering from her season-ending coma while Tyler Galpin (Hunter Doohan) terrorizes both the academy and Jericho town.
Burton’s production faced scheduling conflicts when Ortega’s commitment to the Scream franchise forced reshoots, ultimately dividing Season 2 into two distinct four-episode arcs. “The split allowed us to craft two mini-movies rather than rushing through plot points,” Burton explained during the series’ Netflix promotional campaign. Filmed primarily in Romania with additional sequences in Ireland, the production maintained Burton’s signature gothic aesthetic throughout its complex shooting schedule.
Only Murders in the Building Season 5
Only Murders in the Building Season 5 premieres September 9 on Hulu, reuniting Steve Martin, Martin Short, and Selena Gomez for their most ambitious case yet. Following Sazz Pataki’s (Jane Lynch) mysterious death, the trio investigates connections between wealthy Manhattan moguls, traditional crime families, and the Arconia’s enigmatic residents.
Series creator John Hoffman expanded the cast significantly, adding Meryl Streep, Paul Rudd, and Eva Longoria as recurring characters throughout the ten-episode season. “Season 5 represents our most cinematic approach yet, with each episode functioning as a short film within our larger narrative tapestry,” Hoffman revealed during the series’ Television Critics Association panel. Production occurred across Manhattan locations, with the iconic Arconia building serving as the central hub for the complex murder mystery.
Wayward Debut
Wayward premieres September 25 on Netflix, featuring Mae Martin and Toni Collette in an eight-episode psychological thriller exploring the troubled teen industry. Created by Martin with co-showrunner Ryan Scott, the series follows police officer Alex Dempsey investigating suspicious activities at Tall Pines Academy.
The production faced controversy when advocacy groups criticized the series’ portrayal of residential treatment facilities. However, Martin consulted extensively with survivors and industry watchdogs to ensure authentic representation. “We’re not exploiting trauma for entertainment—we’re exposing institutional failures that continue harming vulnerable teenagers,” Martin emphasized during the Toronto International Film Festival premiere, where Wayward received critical acclaim for its sensitive handling of difficult subject matter.
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